Anti-inflammatory agent 49

Research use only, not for human use.

Anti-inflammatory agent 49 is a potent inhibitor of Drp1-Fis1 interaction, inhibits GTPase, and can be used in the study of diseases caused by mitochondrial dysfunction.

nti-inflammatory agent 49 (compound SC9) is a quite potent and selective inhibitor of Drp1-Fis1 interaction and can reduce FIS1-mediated mitochondrial dysfunction. The IC50 of SC9 inhibiting GTPase in vitro is 270 nM.

Cell Viability Assay Cell Line:H9c2 cells Concentration:2 μM Incubation Time:16?h Result:Decreased the percentage of cells with fragmented mitochondria. The percent of fragmented cells was decreased from 22% (LPS + Veh) to 9% (LPS + SC9), relative to 4% in the absence of LPS.Western Blot Analysis Cell Line:H9c2 cells Concentration:2 μM Incubation Time:24?h Result:Decreased the number of high Drp1-Fis1 cells from 67% (LPS + Veh) to 28% (LPS + P110) and to 14% (LPS + SC9).

Animal Model:Female BALB/c AnNCrl micee (Strain Code 028)Dosage:LPS doses 10–16.67 mg/kg, SC9 doses 10 mg/kg(after 4 h) Administration:Intraperitoneal injection: 0.2 mL of LPS,0.1 mL of CS9; scored every 8 h for 72 h.Result:Improved mouse survival at all LPS doses tested at the different LPS doses (10 to 16.6 mg/kg) .Dramatically reduced the occurrence of critical symptoms such as respiratory distress.

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Others

Other Targets

GTPase

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851471-44-8

466.52

C21H22N8O3S

>98% (HPLC)

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O=C1NC(=O)N(C(N)=C1N(C(=O)CSC=2N=C3N=C(C=C(N3N2)C)C)C)CC=4C=CC=CC4

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(-20℃)

With Ice Pack

≥ 2 years